Font Size: Large | Normal | Small
Font Face: Verdana | Geneva | Georgia

Acmella oleracea, also known under its old names Spilanthes oleracea and Spilanthes acmella and commonly referred to as Spilanthes Extract, is a flowering herb in the plant family Asteraceae, also known as toothache plant or paracress as the leaves and flower heads contain an analgesic agent spilanthol used to numb toothache. It is native to the tropics of Brazil, and is grown as an ornamental (and occasionally as a medicinal) in various parts of the world. A small, erect plant, it grows quickly and sends up gold and red flower inflorescences. It is frost-sensitive but perennial in warmer climates.

For culinary purposes, small amounts of shredded fresh leaves add a unique flavour to salads. Cooked leaves lose their strong flavour and may be used as leafy greens. Both fresh and cooked leaves are used in dishes (such as stews) in Northern parts of Brazil, especially in the state of Par?, often combined with chillies and garlic to add flavor and vitamins to other foods.^[1] A related species is used in several Southeast Asian dishes, such as salads. Consumption of portions or whole flowers have been reportedly used to offset the intense heat of chillies and peppers.^{[citation needed]}

Eating a whole flower bud results in a grassy taste, followed by an extremely strong tingling or numbing sensation and often excessive saliva production and a cooling sensation in the throat.^[1] These buds are known as Buzz Buttons, Szechuan buttons, sansho buttons, and electric buttons.^[2] In India, the buds are used as flavoring in chewing tobacco.^[2]

The leaves of this plant is used by Bodo-tribals of Bodoland, Assam (India) in preparing a spicy chicken soup, mixed with other common spices. Bodos believe that this soup provides relief from cold and cough.

Medical uses and effects

A decoction or infusion of the leaves and flowers is a traditional remedy for stammering, toothache, stomatitis,^[1] and throat complaints.^{[citation needed]}

Acmella oleracea extract has been tested against various yeasts and bacteria and was essentially inactive.^[3]

Acmella oleracea has been shown to have a strong diuretic action in rats.^[4]

Spilanthes extract has been discovered to aid in saliva stimulation for people suffering from dry mouth (xerostomia).^{[citation needed]} Its properties provide relief to dry mouth by enhancing saliva production.^{[citation needed]}

Active chemicals

Spilanthol, (2E,6Z,8E)-deca-2,6,8-trienoic acid isobutyl amide

(2E,7Z,9E)-Undeca-2,7,9-trienoic acid isobutyl amide, another alkylamide from Acmella oleracea

(2E)-Undeca-2-en-8,10-diynoic acid isobutyl amide

The most important taste-active molecules present are fatty acid amides such as spilanthol, which is responsible for the trigeminal and saliva-inducing effects of products such as Jambu oleoresin, a concentrated extract from Paracress.^[5]

Besides the main active ingredient spilanthol, Acmella also contains stigmasteryl-3-O-b-D-glucopyranoside and a mixture of triterpenes.

The isolation and total synthesis of the active ingredients have been reported.^[6]

Pesticide effects

Extracts using hexane of freshly harvested flowers of S. acmella were bioassayed against Aedes aegypti (yellow fever mosquito) larvae and Helicoverpa zea (the corn earworm moth) neonates. Spilanthol proved effective at killing mosquitoes, with an LD₁₀₀ (at 24 hours) at a concentration of 12.5 ?g/mL and showed 50% mortality at 6.25 ?g/mL.

The mixture of isomers of spilanthol showed a 66% weight reduction of H. zea neonate larvae at 250  ;?g/mL concentration after 6 days.^[5]

Acmella oleracea has been shown to have a strong diuretic action in rats.^[4]

Spilanthes extract has been discovered to aid in saliva stimulation for people suffering from dry mouth (xerostomia).^{[citation needed]} Its properties provide relief to dry mouth by enhancing saliva production.^{[citation needed]}

Active chemicals

Spilanthol, (2E,6Z,8E)-deca-2,6,8-trienoic acid isobutyl amide

(2E,7Z,9E)-Undeca-2,7,9-trienoic acid isobutyl amide, another alkylamide from Acmella oleracea

(2E)-Undeca-2-en-8,10-diynoic acid isobutyl amide

The most important taste-active molecules present are fatty acid amides such as spilanthol, which is responsible for the trigeminal and saliva-inducing effects of products such as Jambu oleoresin, a concentrated extract from Paracress.^[5]

Besides the main active ingredient spilanthol, Acmella also contains stigmasteryl-3-O-b-D-glucopyranoside and a mixture of triterpenes.

The isolation and total synthesis of the active ingredients have been reported.^[6]

Pesticide effects

Extracts using hexane of freshly harvested flowers of S. acmella were bioassayed against Aedes aegypti (yellow fever mosquito) larvae and Helicoverpa zea (the corn earworm moth) neonates. Spilanthol proved effective at killing mosquitoes, with an LD₁₀₀ (at 24 hours) at a concentration of 12.5 ?g/mL and showed 50% mortality at 6.25 ?g/mL.

The mixture of isomers of spilanthol showed a 66% weight reduction of H. zea neonate larvae at 250 ?g/mL concentration after 6 days.^[5]

References

External links

• PROTAbase on Acmella oleracea